German landline, mobile and out of Germany possibly more expensive). In Brief Mukherjeeetal.foundthatgliaprovidean antioxidant defense system to support neurons against iron-mediated cytotoxicity inDrosophila.In mice, ferritin heavy chain is secreted by oligodendrocytes, … Mail: anja.schneider@ukbonn.de Phone: 0228 287 14715 Web: UKB and DZNE. She is a full professor of clinical dementia research at Bonn University and Chair of the Department of Neurodegenerative Diseases and Geriatric Psychiatry at Bonn University Hospital as well as senior group leader in translational dementia research at the German Research Center of Neurodegenerative Diseases (DZNE) in Bonn. E‐mail: nico.mitro@unimi.it (or) Anja Schneider, German Center for Neurodegenerative Diseases, DZNE, Sigmund‐Freud‐Str. Furthermore, we are interested in oligodendroglial pathology in neurodegenerative diseases. (2)Deutsches Zentrum für Neurodegenerative Erkrankungen, DZNE, Bonn, … anja.schneider@dzne.de +49 228 43302-450 Curriculum vitae Research areas/focus Group members Publications. If you need immediate assistance, call 877-SSRNHelp (877 777 6435) in the United States, or +1 212 448 2500 outside of the United States, 8:30AM to 6:00PM U.S. Eastern, Monday - Friday. Areas of investigation/research focus We investigate extracellular vesicles (EVs) in neurodegenerative diseases. Relevant conflicts of Interest/financial disclosures: The authors declare no conflicts of interest. We investigate extracellular vesicles (EVs) in neurodegenerative diseases. Kunadt M, Eckermann K, Strauss K, Rai S, Kügler S, Stündl A, Lockhart LF, Schwalbe M, Krumova P, Oliveira L, Bähr M, Möbius W, Ludolph AC, Levin J, Giese A, Kruse N, Mollenhauer B, Geiss-Friedlander R, Freischmidt A, Feiler M, Danzer KM, Zweckstetter M, Jovin T, Simons M, Weishaupt JH, Schneider A. Strauss K., Goebels C., Moebius W., Weiss S., Runz H., Feussner I., Simons M., Schneider A. Rajendran L., Schneider A., Schlechtingen G., Weidlich S., Ries J., Braxmeier T., Schwille P., Schulz J.B., Schroeder C., Simons M., Jennings G., Knoelker H.J., Simons K. (9 Cent/Min. Frederic Brosseron, Klaus Fliessbach, Michael T. Heneka, Alexandra Polcher, Anja Schneider, Michael Wagner & Steffen Wolfsgruber. Neurotherapeutics. PMID: 29423820 DOI: 10.1007/s00115-018-0488-2 Abstract In the field of prodromal Alzheimer's disease biomarker-based diagnostics are becoming increasingly more important. Her recent studies show, that extracellular vesicles derived from oligodendroglia protect neurons from oxidative damage, and may thus be important in neurodegenerative diseases. Dr. Schneider also performs clinical research including intervention trials in Alzheimerâs disease and she is PI of the DZNE multicenter, longitudinal cohort DESCRIBE FTD. Register for email updates about our latest news: © 2005 - 2021 Cure Alzheimer's Fund. 27 Venusberg-Campus D-53127 Bonn. Applications will be considered until the position is filled. Anja Schneider Prof. Anja Schneider is the Director of the Department of Neurodegenerative Disease and Geriatric Psychiatry at the University Clinic of Bonn and Research Group Leader Translational Dementia Research at the German Center for Neurodegenerative Diseases (DZNE) . "We therefore used an experimental drug that was known to have an anti-inflammatory effect," says Prof. Anja Schneider, head of a research group at the DZNE in Bonn. Prof. Dr. Anja Schneider (DZNE, Bonn) Extracellular Vesicles in Neurodegeneration and Diseases. | 2018. German Center for Neurodegenerative Diseases (DZNE) Sigmund-Freud-Str. However, how neuronal EVs contribute to trans-neuronal signaling is largely elusive. In the field of prodromal Alzheimer's disease biomarker-based diagnostics are becoming increasingly more important. Research Focus. Anja Schneider from the DZNE in Bonn hopes to find biomarkers in the blood that will allow neurodegenerative diseases such as Alzheimer’s to be identified at a very early stage. INTRODUCTION Impaired long-term memory is a defining feature of Mild Cognitive Impairment (MCI). We investigate extracellular vesicles (EVs) in neurodegenerative diseases. We investigate extracellular vesicles (EVs) in neurodegenerative diseases. Bartels C, Wolfsgruber S, Wagner M, Ehrenreich H, Schneider A. Anne Stuendl, Marcel Kunadt, Niels Kruse, Claudia Bartels, Wiebke Moebius, Karin M. Danzer, Brit Mollenhauer, Anja Schneider. Unclear biomarker constellations, such as suspected non-Alzheimer pathology (SNAP) can lead to diagnostic and prognostic uncertainty. Anja Schneider, Oliver Speck, Eike Jakob Spruth, Stefan Teipel, Ruth Vukovich, Christine Westerteicher, Jens Wiltfang, Steffen Wolfsgruber, Michael Wagner, Emrah Düzel; Affiliations Frank Jessen German Center for Neurodegenerative Diseases (DZNE) Annika Spottke German Center for Neurodegenerative Diseases (DZNE) Applications will be considered until the position is filled. *Correspondence to:Dr. Anja Schneider, German Center for Neurodegenerative Diseases, DZNE, Venusberg Campus 1, 53127 Bonn, Germany; E-mail: anja.schneider@dzne.de †Equal contribution. E-mail: anja.schneider@dzne.de Abbreviations used: 4E-BP1, eukaryotic translation initiation factor 4E-binding protein 1; AD, Alzheimer’s disease; AKT, AKT Serine/Threonine kinase 1; ALS, amyotrophic lateral sclerosis; AMBRA1, autophagy and beclin 1 regulator 1; AMPK, AMP-activated protein kinase; APP, amyloid All rights reserved. The DZNE is an equal opportunity employer. 27, 53127 Bonn, Germany. "We therefore used an experimental drug that was known to have an anti-inflammatory effect," says Prof. Anja Schneider, head of a research group at the DZNE in Bonn. Anja Schneider, M.D. For further information, please contact anja.schneider@dzne.de. For further information, please contact anja.schneider@dzne.de. Fließbach K(1)(2), McCormick C(1)(2), Kaulen B(1)(2), Schneider A(3)(4). All data are pseudonymous and are only used by the DZNE. Ayse Ulusoy, Ruth E Musgrove, Raffaella Rusconi, Michael Klinkenberg, Michael Helwig, Anja Schneider, and Donato A Di Monte Ayse Ulusoy German Center for Neurodegenerative Diseases (DZNE), Ludwig-Erhard-Allee … Anja Schneider, Eckhard Mandelkow, One example of translation from basic research into clinical application within the DZNE is our currently recruiting phase Ib trial testing the safety and tolerability of Vorinostat in patients with mild Alzheimer’s disease. She received her M.D. 2. You will obtain special skills and knowledge for your scientific qualification during your activities at DZNE. Please apply via the link below. Total downloads of all papers by Anja Schneider. from Hamburg University, Germany and completed her residency at Tübingen and Göttingen University Medical Centers. We … *Corresponding author. Dr. Schneider is a psychiatrist specializing in neurodegenerative dementia. Professor and Director, Clinic for Neurodegenerative Diseases and Gerontopsychiatry, Bonn University Hospital; Senior Group Leader, German Research Center of Neurodegenerative Diseases (DZNE). ... For this cross‐sectional analysis, baseline data of N = 687 from the DZNE Longitudinal Cognitive Impairment and … Another line of research in her lab is the development of fluid biomarkers in Alzheimerâs and Parkinsonâs disease. Overview of the Workshops Feb. 04, 2021 8.30 - 11.00 a.m. - WP 1 Integrative data handling for improved human health research Katarzyna Bozek and Philipp Antczak. An important aspect of our work is the translation from basic research to clinical application and vice versa. Design and first baseline data of the DZNE multicenter observational study on predementia ... Laske, 13, 14 Felix Menne, 10 Peter Nestor, 15 Oliver Peters, 10, 16 Josef Priller, 9, 16 Verena Pross, 1 Alfredo Ramirez, 2, 8, 17 Anja Schneider, 1, 7 Oliver Speck, 18 Eike Jakob Spruth, 9 Stefan Teipel, 11, 12 Ruth Vukovich, 19 … anja.schneider@dzne.de +49 228 43302-450 Curriculum Vitae Forschungsschwerpunkte Gruppenmitglieder Publikationen. In addition, we are focus on the detection of novel biomarkers from blood and cerebrospinal fluid (CSF) which may enable diagnosis and prognosis of neurodegenerative diseases in the prodromal or even preclinical stage. Using methods such as the so-called amyloid PET scan, hazardous amyloid plaques can already be detected in the brain at an early stage – but to do … Katharina Buerger & Robert Perneczky Anja Schneider German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany Department for Neurodegenerative Diseases and Geriatric Psychiatry, University Hospital Bonn, Bonn, Germany Anja Schneider, Manuel Maler, Maryna Polyakova, Lina Riedl, Jens Wiltfang and ; Georg Ziegler; 1 German Center for Neurodegenerative Diseases (DZNE) and Munich Cluster for System Neurology (SyNergy), Munich, Germany; 2 Department of Neurology, Ulm University Hospital, Ulm, Germany German Center for Neurodegenerative Diseases (DZNE) Venusberg-Campus 1 53175 Bonn, ... Email: Anja.Schneider(at)dzne.de. Forschungsschwerpunkte Wir untersuchen extrazelluläre Vesikel (EV) bei neurodegenerativen Erkrankungen. 1. Prof. Dr. Anja Schneider German Center for Neurodegenerative Diseases (DZNE), Göttingen Members of the Examination Board Members of the Thesis Committee and Prof. Dr. Dr. Hannelore Ehrenreich Department of Clinical Neuroscience, Max-Planck Institute of Experimental Medicine, Göttingen Prof. Dr. André Fischer 2008 Jul;5(3):443 … Electronic address: anja.schneider@dzne.de. For further information, please contact anja.schneider@dzne.de. Author information: (1)Klinik für Neurodegenerative Erkrankungen und Gerontopsychiatrie, Universitätsklinikum Bonn Venusberg, Campus 1, 53127, Bonn, Deutschland. Please apply via the link below. Professor and Director, Clinic for Neurodegenerative Diseases and Gerontopsychiatry, Bonn University Hospital; Senior Group Leader, German Research Center of Neurodegenerative Diseases (DZNE) Dr. Schneider is a psychiatrist specializing in neurodegenerative dementia. Objective: To determine if following a Mediterranean-like diet (MeDi) relates to cognitive functions and in vivo biomarkers for Alzheimer’s disease (AD), we analyzed cross-sectional data from the German Longitudinal Cognitive Impairment and Dementia Study Method: The sample (n=512, mean age: 69.5±5.9 years) … Reversal of Tau Pathology by an Adenosine A1 Receptor Antagonist. Cure Alzheimerâs Fund is a âdoing business asâ name for the Alzheimerâs Disease Research Foundation, a 501(c)(3) public charity with federal tax ID #52-239-6428. Website. Overall study design. We deliberately avoid third-party cookies. We are especially interested in EV mediated release of toxic, aggregated proteins, such as a-Synuclein, the determinants of their sorting into EVs and the contribution of their release to toxicity and propagation of disease pathology throughout the brain. Schneider A. We set up the study protocol based on findings by A. Fischer’s group at DZNE Göttingen showing that Vorinostat can reinstate memory deficits in an Alzheimer’s disease mouse model. Welcome to our website, here you can inform yourself basically cookie-free. These projects were made possible from Cure Alzheimer's Fund support. 8 German Center for Neurodegenerative Diseases (DZNE), 53127 Bonn, Germany; Department of Neurodegenerative Diseases and Geriatric Psychiatry, University Bonn, 53127 Bonn, Germany. Alzheimer’s disease (AD) pathology precedes the onset of clinical symptoms by several decades. Eva-Maria Mandelkow, We would be pleased if you would allow a cookie to be set for analysis purposes in order to optimise our provided information. *, Simons M. Exosomes-vesicular carriers for intercellular communication in neurodegenerative disorders Cell and Tissue Research, in press. Anja Schneider. Extracellular vesicles (EVs) have emerged as novel regulators of several biological processes, in part via the transfer of EV content such as microRNA; small non-coding RNAs that regulate protein production, between cells. the effects of oligodendroglial EVs, using primary cell culture and mouse models. DELCODE is an observational longitudinal memory clinic-based multicenter study in Germany. We tested whether this impairment is item-specific, limited to some memoranda whereas some remain consistently memorable. Please apply via the link below German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany. It is committed to employing disabled individuals and especially encourages them to apply. German Center for Neurodegenerative Diseases (DZNE, Munich), Feodor-Lynen-Strasse 17, 81377, Munich, Germany. You can deselect this setting at any time here. Anja.Schneider@dzne.de. E‐mail: anja.schneider@dzne.de Search for more papers by this author Anja.Schneider@dzne.de. Dr. Schneider has received several awards and honors for her work, including among others the German Mental Health Associationâs Price for Therapeutic Research, a Heisenberg Fellowship from the German Research Foundation and the German Alzheimerâs Hirnligaâs Steinberg-Krupp Prize. The participants to be enrolled are 400 subjects with SCD, 200 MCI patients, 100 AD dementia patients, 200 control subjects without subjective or objective cognitive decline, and 100 first-degree relatives of … We … Anja Schneider. METHODS We conducted item-based analyses of long-term visual recognition … German Center for Neurodegenerative Diseases (DZNE), 37075 Göttingen, Germany Correspondence to Anja Schneider: anja.schneider@dzne.de ; or Mikael Simons: msimons@gwdg.de Search for other works by this author on: Her lab focuses on the pathological mechanisms of neurodegenerative diseases, in particular the role of extracellular vesicles in propagation of disease pathology. Your browser allows the setting of cookies. We also explore physiological functions of EVs in the CNS, e.g. … Schneider A., Mandelkow E. Tau-based treatment strategies in neurodegenerative diseases. Anja Schneider, Mikael Simons Correspondence anja.schneider@dzne.de (A.S.), mikael.simons@dzne.de (M.S.) Interviews will first be conducted via video conference, followed by a possible on-site visit to Bonn.
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